Volume 12, Issue 1 (2026)
CJP 2026, 12(1): e5 |
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Sadatinejad S M, Jafari M, Etesam S, Kaji Yazdi M. Effect of Garlic Tablets on COVID-19–Associated Gastroenteritis in Children Aged 2–10 Years: A Double-Blind Randomized Controlled Trial. , CJP. 2026; 12 (1) : e5
URL: http://caspianjp.ir/article-1-283-en.html
URL: http://caspianjp.ir/article-1-283-en.html
Associate Professor of Pediatric Hematology and Oncology, Department of Pediatrics, School of Medicine, Bahrami Hospital, Tehran University of Medical Sciences , mkajiyazd50@gmail.com
Abstract: (17 Views)
Background and Objective: COVID-19-associated gastroenteritis is a major concern in pediatrics. Given the reported antiviral properties of garlic, this study investigated its effectiveness in managing COVID-19-associated gastroenteritis in children aged 2 to 10 years.
Methods: This double-blind, placebo-controlled randomized clinical trial was conducted between 2020 and 2022 at Bahrami Children's Hospital in Tehran. Fifty-five children with COVID-19-associated gastroenteritis were enrolled using convenience sampling, including 30 in the control group and 25 in the intervention group,. The inclusion criteria were a diagnosis of COVID-19-associated gastroenteritis, age 2–10 years, and parental informed consent. Patients with underlying diseases or severe COVID-19 complications were excluded. The intervention group received one 400-mg garlic tablet daily, and the control group received a placebo along with routine supportive care. Demographic, clinical, and laboratory data were collected and analyzed using SPSS16 (P<0.05).
Findings: Garlic tablets did not significantly reduce the frequency of diarrhea, bloody diarrhea, or vomiting. Furthermore, no significant differences were observed between the two groups in terms of the need for adjunctive medications (antibiotics, antivirals, anticoagulants, corticosteroids), length of hospital stay, or laboratory findings, including CRP, ESR, ferritin, PT, PTT, INR, CPK, AST, ALT, and white blood cell counts.
Conclusion: This study found no significant effect of garlic tablets on diarrhea, bloody diarrhea, vomiting, need for adjunctive medications, improvement in laboratory parameters, or length of hospital stay in children with COVID-19-associated gastroenteritis. Further interventional studies with larger sample sizes are warranted.
Methods: This double-blind, placebo-controlled randomized clinical trial was conducted between 2020 and 2022 at Bahrami Children's Hospital in Tehran. Fifty-five children with COVID-19-associated gastroenteritis were enrolled using convenience sampling, including 30 in the control group and 25 in the intervention group,. The inclusion criteria were a diagnosis of COVID-19-associated gastroenteritis, age 2–10 years, and parental informed consent. Patients with underlying diseases or severe COVID-19 complications were excluded. The intervention group received one 400-mg garlic tablet daily, and the control group received a placebo along with routine supportive care. Demographic, clinical, and laboratory data were collected and analyzed using SPSS16 (P<0.05).
Findings: Garlic tablets did not significantly reduce the frequency of diarrhea, bloody diarrhea, or vomiting. Furthermore, no significant differences were observed between the two groups in terms of the need for adjunctive medications (antibiotics, antivirals, anticoagulants, corticosteroids), length of hospital stay, or laboratory findings, including CRP, ESR, ferritin, PT, PTT, INR, CPK, AST, ALT, and white blood cell counts.
Conclusion: This study found no significant effect of garlic tablets on diarrhea, bloody diarrhea, vomiting, need for adjunctive medications, improvement in laboratory parameters, or length of hospital stay in children with COVID-19-associated gastroenteritis. Further interventional studies with larger sample sizes are warranted.
Article number: e5
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