en تخصصي Special پژوهشي Research <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="line-height:normal"><b><span style="border: 1pt none windowtext; padding: 0cm;"><span style="color:#24a3a0">Background and Objective:</span></span></b> <span style="color:#1f2023;">COVID-19-associated gastroenteritis is a major concern in pediatrics. Given the reported antiviral properties of garlic, this study investigated its effectiveness in managing COVID-19-associated gastroenteritis in children aged 2 to 10 years.</span></span><br> <span style="line-height:normal"><b><span style="border: 1pt none windowtext; padding: 0cm;"><span style="color:#24a3a0">Methods:</span></span></b> <span style="color:#000000;">This double-blind, placebo-controlled randomized clinical trial was conducted between 2020 and 2022 at Bahrami Children&#39;s Hospital in Tehran. Fifty-five children with COVID-19-associated gastroenteritis were enrolled using convenience sampling, including 30 in the control group and 25 in the intervention group,. The inclusion criteria were a diagnosis of COVID-19-associated gastroenteritis, age 2&ndash;10 years, and parental informed consent. Patients with underlying diseases or severe COVID-19 complications were excluded. The intervention group received one 400-mg garlic tablet daily, and the control group received a placebo along with routine supportive care. Demographic, clinical, and laboratory data were collected and analyzed using SPSS16 (P<0.05).</span></span><br> <span style="line-height:normal"><b><span style="border: 1pt none windowtext; padding: 0cm;"><span style="color:#24a3a0">Findings:</span></span></b> <span style="color:#000000;">Garlic tablets did not significantly reduce the frequency of diarrhea, bloody diarrhea, or vomiting. Furthermore, no significant differences were observed between the two groups in terms of the need for adjunctive medications (antibiotics, antivirals, anticoagulants, corticosteroids), length of hospital stay, or laboratory findings, including CRP, ESR, ferritin, PT, PTT, INR, CPK, AST, ALT, and white blood cell counts.</span></span><br> <span style="line-height:normal"><b><span style="border: 1pt none windowtext; padding: 0cm;"><span style="color:#24a3a0">Conclusion:</span></span></b> <span style="color:#000000;">This study found no significant effect of garlic tablets on diarrhea, bloody diarrhea, vomiting, need for adjunctive medications, improvement in laboratory parameters, or length of hospital stay in children with COVID-19-associated gastroenteritis. Further interventional studies with larger sample sizes are warranted.</span></span></span></span></div> Covid 19, Garlic, Gastroenteritis 0 0 http://caspianjp.ir/browse.php?a_code=A-10-178-7&slc_lang=en&sid=1 Seyyed Mohsen Sadatinejad Sadatinejad71@gmail.com 0000-0002-0456-1644 No Assistant Professor of Pediatric Cardiology , Aliasghar Clinical Research Development Center, Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Mohsen Jafari m_jafari@sina.tums.ac.ir 0000-0002-5823-1632 No Assistant Professor of Pediatric Infectious Diseases, Bahrami Children Hospital, Tehran University of Medical Sciences. Tehran, Iran. Saideh Etesam Dr.s.etesam@gmail.com No Pediatrician, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Kaji Yazdi mkajiyazd50@gmail.com 0000-0003-2743-9817 Yes Associate Professor of Pediatric Hematology and Oncology, Department of Pediatrics, School of Medicine, Bahrami Hospital, Tehran University of Medical Sciences