Volume 11, Issue 1 (2025)
CJP 2025, 11(1): e14 |
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Ghorbani H, Haghshenas Mojaveri M, Pournajaf S, Akbarian-rad Z. Maternal Blood Hemoglobin Electrophoresis for Detecting Fetal Hemoglobin in Severe Fetomaternal Hemorrhage: A Case Report. CJP 2025; 11 (1)
URL: http://caspianjp.ir/article-1-282-en.html
URL: http://caspianjp.ir/article-1-282-en.html
Associate Professor of Neonatal-Perinatal Medicine, Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran , zhr_akbarian@yahoo.com
Abstract: (38 Views)
Background and Objective: Massive form of fetomaternal hemorrhage (FMH) is a rare event in pregnancy, and it is a crucial cause of severe neonatal anemia at birth. The standard test for detecting fetal red cells in maternal blood is the Keilhauer–Betke test (KBT). In this case, we detected fetal hemoglobin (HbF) by electrophoresis of the maternal blood.
Case Report: A male neonate with gestational age 37+6 weeks was born by cesarean section (C/S) due to decreased fetal activity that occurred since 16 hours before delivery and a non-reactive non-stress test (NST). The baby received positive pressure ventilation due to no breath and hypotonia at birth. The baby's skin was severely pale, with no signs of edema, ecchymosis, petechiae, hepatosplenomegaly, or ascites. An emergency complete blood cell count (CBC) revealed a hemoglobin (Hb) level of 3.1 g/dL and a hematocrit of 11.1%. After transferring the patient to the neonatal intensive care unit, blood transfusion was performed according to protocol. As the KBT was not available, we detected HbF in the maternal blood by Hb Electrophoresis (HbF=5.3%). The baby was discharged in good clinical condition, and there was no clinical problem for his mother.
Conclusion: Maternal blood Hb electrophoresis can be helpful for the diagnosis of FMH if an expert in KBT is not available.
Case Report: A male neonate with gestational age 37+6 weeks was born by cesarean section (C/S) due to decreased fetal activity that occurred since 16 hours before delivery and a non-reactive non-stress test (NST). The baby received positive pressure ventilation due to no breath and hypotonia at birth. The baby's skin was severely pale, with no signs of edema, ecchymosis, petechiae, hepatosplenomegaly, or ascites. An emergency complete blood cell count (CBC) revealed a hemoglobin (Hb) level of 3.1 g/dL and a hematocrit of 11.1%. After transferring the patient to the neonatal intensive care unit, blood transfusion was performed according to protocol. As the KBT was not available, we detected HbF in the maternal blood by Hb Electrophoresis (HbF=5.3%). The baby was discharged in good clinical condition, and there was no clinical problem for his mother.
Conclusion: Maternal blood Hb electrophoresis can be helpful for the diagnosis of FMH if an expert in KBT is not available.
Keywords: Anemia, Neonatal, Blood Protein Electrophoresis, Fetal Hemoglobin, Fetomaternal Transfusion, Kleihauer-Betke Test
Type of Study: case report |
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