[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 1, Issue 1 (3-2015) ::
CJP 2015, 1(1): 5-8 Back to browse issues page
Preventive Effect of Clofibrate on Neonatal Hyperbilirubinemia
Yadollah Zahed Pasha , Sadroddin Mahdipour * , Mousa Ahmadpour-Kacho , Ali Bijani , Maryam Taheri
Pediatrics Growth Disorders Research Center, 17 Shahrivar Pediatric Hospital, School of Medicine , smb1355@gmail.com
Abstract:   (11937 Views)

Background: Neonatal jaundice is a common problem that can result in serious neurological side effect such as Kern icterus. Several drugs are used to prevent neonatal jaundice. The effect of clofibrate in the prevention of hyperbilirubi-nemia in healthy term neonates has not been paid attention to. This study aimed to evaluate the preventive effect of clofibrate on neonatal jaundice in term neonates.

Methods: This clinical trial was conducted on 80 healthy newborns randomly divided in to cases and control groups. The case group received clofibrate (50 mg/kg of body weight) orally in the first hour after birth and after the first period of breastfeeding. Serum bilirubin levels were measured in cord blood and again at 24, 48 and 72 hours after birth in both groups and were compared. Babies with clear jaundice on the first day, direct neonatal jaundice>1 mg/dl, sick infants, and infants of mothers treated with phenobarbital and preterm infants weighing less than 2500 gr were excluded.

Results: The mean bilirubin level in cord blood and its level at 24, 48 and 72 hours after birth in control groups were 1.99±0.46, 2.88±0.88, 5.94±1.15, 7.65±1.69, respectively and in the case group were 2.12±0.75, 2.89±0.95, 5.8±1.16, 7.18±1.57, respectively. Thus, the mean bilirubin in the case group is lower, but it was not statistically significant. Also, sex distribution, Rh-blood group incompatibility and G6PD deficiency in both groups showed no significant difference.

Conclusions: Our results showed that prophylactic clofibrate application reduced neonatal hyperbilirubinemia, but wasn’t statistically significant.

Keywords: Clofibrate, Neonatal, Jaundice, Prevention
Full-Text [PDF 311 kb]   (1240 Downloads)    
Type of Study: Applicable | Subject: Special
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Zahed Pasha Y, Mahdipour S, Ahmadpour-Kacho M, Bijani A, Taheri M. Preventive Effect of Clofibrate on Neonatal Hyperbilirubinemia. CJP. 2015; 1 (1) :5-8
URL: http://caspianjp.ir/article-1-25-en.html


Volume 1, Issue 1 (3-2015) Back to browse issues page
مجله کودکان کاسپین Caspian Journal of Pediatrics
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3638