Volume 10, Issue 1 (3-2024)
CJP 2024, 10(1): e18 |
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Shahgholi E, Sadatinejad S M, Kajiyazdi M. The Relationship between Early Clinical Presentation, Laboratory Data, and Minimal Residual Disease of Acute Lymphoblastic Leukemia with Cytogenetic Findings in Children. CJP 2024; 10 (1)
URL: http://caspianjp.ir/article-1-243-en.html
URL: http://caspianjp.ir/article-1-243-en.html
Associate Professor of Pediatric Hematology and Oncology, Tehran University of Medical Sciences, Tehran, Iran , eshahgholi@gmail.com
Abstract: (2 Views)
Background and Objective: Eighty percent of childhood leukemia cases are classified as acute lymphocytic leukemia (ALL), with genetic abnormalities identified in the majority of instances. We conducted an examination of the early clinical manifestations of pediatric ALL and the minimal residual disease (MRD) following treatment with standard cytogenetic testing in children.
Methods: This descriptive and analytical study involved patients diagnosed with ALL who were admitted to three hospitals in Tehran, Iran, from 2020 to 2021. The clinical features assessed included splenomegaly, hepatomegaly, and lymphadenopathy. Laboratory tests conducted comprised complete blood count, lactate dehydrogenase levels, tumor lysis tests, bone marrow aspiration, MRD assessment, and cytogenetic analysis, with a p-value<0.05 considered statistically significant.
Methods: This descriptive and analytical study involved patients diagnosed with ALL who were admitted to three hospitals in Tehran, Iran, from 2020 to 2021. The clinical features assessed included splenomegaly, hepatomegaly, and lymphadenopathy. Laboratory tests conducted comprised complete blood count, lactate dehydrogenase levels, tumor lysis tests, bone marrow aspiration, MRD assessment, and cytogenetic analysis, with a p-value<0.05 considered statistically significant.
Findings: A total of eighty-four patients participated in the study. No significant associations were identified between early splenomegaly, lymphadenopathy, limping, tumor lysis, mediastinal mass, and cytogenetics or MRD. Hepatomegaly was found to correlate with the absence of unfavorable structural mutations, whereas anemia was associated with the presence of mutations. A white blood cell (WBC) count of less than 50,000/µl was linked to lower MRD levels, and a platelet count of less than 50,000/µl was associated with the del9p21 mutation and unidentified structural mutations (P<0.05). Additionally, lactate dehydrogenase (LDH) levels of less than 1000 IU/L were related to unfavorable numerical mutations.
Conclusion: This study found that anemia, a platelet count below 50,000, and LDH levels under 1,000 are significantly associated with mutations and cytogenetics. Further controlled studies in this area could be beneficial.
Keywords: Acute Lymphoblastic Leukemia, Child, Clinical Laboratory Test, Cytogenetic, Signs and Symptoms
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