Volume 7, Issue 1 (3-2021)
CJP 2021, 7(1): 0 |
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Ahmadpour-kacho M, Zahed Pasha Y, Zeynalzadeh M, Hajiahmadi M, Kalantar M, Baleghi M et al . Effect of antenatal steroid before elective cesarean section on prevention of respiratory morbidities of full-term neonates. CJP 2021; 7 (1) :472-478
URL: http://caspianjp.ir/article-1-113-en.html
URL: http://caspianjp.ir/article-1-113-en.html
Mousa Ahmadpour-kacho * 
, Yadollah Zahed Pasha , Mahtab Zeynalzadeh , Mahmoud Hajiahmadi , Mohammadhosein Kalantar , Mehrangiz Baleghi , Tahereh Jahangir
, Yadollah Zahed Pasha , Mahtab Zeynalzadeh , Mahmoud Hajiahmadi , Mohammadhosein Kalantar , Mehrangiz Baleghi , Tahereh Jahangir
Professor of Neonatolgy, Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran. , mousa_ahmadpour@hotmail.com
Abstract: (3435 Views)
Background and Objective: Elective cesarean section (ECS) increases neonatal respiratory complications like transient tachypnea of the newborn (TTN) and respiratory distress syndrome (RDS). This pilot study examined the effect of antenatal steroids on the prevention of respiratory problems in full-term neonates born via ECS.
Methods: This experimental study was carried out on full-term neonates (39-42 weeks) born by ECS to the mothers admitted to Babol Clinic Hospital, northern, Iran in 2016. The intervention group received betamethasone (12 mg, intramuscular, once a day) for 2 days before ECS plus conventional care, but the control group received only conventional care. The rate of respiratory complication and the admission rate of the newborn ward and neonatal intensive care unit (NICU) were compared between two groups.
Findings: Overall, 200 full-term neonates (100 neonates in the experimental group and 100 neonates in the control group) were enrolled. Nine neonates (9%) in the experimental group and 8 neonates (8%) in the control group had TTN (P=0. 64), and one (1%) neonate in the experimental group and one neonate (1%) in the control group had RDS (P=1).
Conclusion: Antenatal corticosteroid administration to the mothers before ECS with gestational ages of 39-42 weeks does not reduce the incidence of respiratory complications. Thus, further studies are needed to determined its effects in gestational age group more than 39 weeks.
Methods: This experimental study was carried out on full-term neonates (39-42 weeks) born by ECS to the mothers admitted to Babol Clinic Hospital, northern, Iran in 2016. The intervention group received betamethasone (12 mg, intramuscular, once a day) for 2 days before ECS plus conventional care, but the control group received only conventional care. The rate of respiratory complication and the admission rate of the newborn ward and neonatal intensive care unit (NICU) were compared between two groups.
Findings: Overall, 200 full-term neonates (100 neonates in the experimental group and 100 neonates in the control group) were enrolled. Nine neonates (9%) in the experimental group and 8 neonates (8%) in the control group had TTN (P=0. 64), and one (1%) neonate in the experimental group and one neonate (1%) in the control group had RDS (P=1).
Conclusion: Antenatal corticosteroid administration to the mothers before ECS with gestational ages of 39-42 weeks does not reduce the incidence of respiratory complications. Thus, further studies are needed to determined its effects in gestational age group more than 39 weeks.
Keywords: Betamethasone, Cesarean Section, Glucocorticoids, Newborn, Respiratory Distress Syndrome, Term Birth, Transient Tachypnea of the Newborn
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- The administration of antenatal corticosteroids at gestational age of 39-42 weeks did not significantly reduce respiratory complications.
- It seems illogical to prescribe corticosteroid in gestational ages >39 weeks.
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