en تخصصي Special پژوهشي Research <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#008080;"><strong><em>Background:</em></strong> </span>Neonatal seizure is a common problem and associated with a great mortality rate, high risk of chronic neurodevelopmental impairments, also difficult to diagnosis and treatment. The aim of this study was to determine the neurodevelopmental outcome, clinical presentation and etiology of seizures in neonates admitted to Amirkola Children&#39;s Hospital (ACH).<br> <span style="color:#008080;"><strong><em>Methods:</em></strong> </span>In this cross-sectional study, 42 neonates with the initial diagnosis of seizure, aged less than 28 days, hospitalized in ACH, northern Iran, from April to September 2016 were selected using convenient sampling method. The patients&#39; information was gathered during hospitalization period and 6 months after discharge. Data were analyzed using SPSS 22 through descriptive and chi-square tests.<br> <span style="color:#008080;"><strong><em>Results:</em></strong></span> Among preterm and term neonates with seizures, the main diagnosis in neonates with seizures was idiopathic (38.1%) and hypoxic-ischemic encephalopathy (HIE) (14.3%), hypoglycemia (9.5 %) hypomagnesaemia (7.1%) and opiate withdrawal (4.8%). Twenty-three neonates underwent brain computed tomography (CT) scan and 6 (14.3%) of them had abnormal brain imaging. Seizure control with antiepileptics (P=0.006), metabolic disturbance (P=0.002) and time of drug discontinuation (P<0.001) were significantly associated with adverse neurodevelopmental outcome.<br> <span style="color:#008080;"><strong><em>Conclusions:</em></strong></span> Since idiopathic encephalopathy and HIE were the most common cause of neonatal seizures, it should be attempted to improve care during delivery.</span></span></div> Neurodevelopmental outcome, Newborn, Seizures 308 312 http://caspianjp.ir/browse.php?a_code=A-10-37-1&slc_lang=en&sid=1 Mohammadreza Salehiomran salehiomran@yahoo.com 10031947532846002683 10031947532846002683 No Non-Communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran Samane Araby samane_araby@yahoo.com 10031947532846002684 10031947532846002684 Yes Pediatrician, Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Mousa Ahmadpour-kacho mousa.ahmadpour@hotmail.com 10031947532846002685 10031947532846002685 No Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran Mahmoud Hajiahmadi hajiahmadi@yahoo.com 10031947532846002686 10031947532846002686 No Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran. Tahereh Jahangir zoya.t.jahangir@gmail.com 10031947532846002687 10031947532846002687 No The Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, IR Iran