en تخصصي Special پژوهشي Research <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#008080;"><strong><em>Background:</em></strong> </span>Background: Obesity, especially central obesity is related to many endocrine abnormalities, such as thyroid dysfunctions. Elevated levels of thyroid stimulating hormone (TSH) is common in obese children, however, it is not clear if such condition is associated with increased cardiovascular risk factors. The study aimed to determine the association between levels of TSH in overweight and obese children with components of metabolic syndrome (Mets).<br> <span style="color:#008080;"><strong><em>Methods:</em></strong> </span>The study sample included 197 overweight/obese 6-7 year old children in Tehran, Iran. Anthropometric (weight, waist circumference and height), metabolic (high-density lipoprotein cholesterol, triglycerides and fasting blood glucose) and hormonal (TSH) variables, as well as blood pressure were measured. Mets was defined according to Cook definition.<br> <span style="color:#008080;"><strong><em>Results:</em></strong></span> Totally, 20.3% and 79.7% of children were overweight and obese, respectively. Elevated levels of TSH were diagnosed in 10 subjects (5.1%), while Mets was seen in 35.4%. The most frequent component of Mets was abdominal obesity (72.5%). A weak positive correlation between BMI for age, Z scores and TSH level (r =0.11, P value= 0.123) was observed only in girls (r=0.2, P value= 0.034). TSH was not associated with components of Mets.<br> <span style="color:#008080;"><strong><em>Conclusion:</em></strong></span> Elevated TSH levels may be found in obese children; however, the association between TSH elevation and cardiovascular disease risk factors, including components of metabolic syndrome needs further investigation.</span></span></p> Hypothyroidism, Overweight, Metabolic Syndrome, Cardio Vascular Risk Factor 224 228 http://caspianjp.ir/browse.php?a_code=A-10-103-1&slc_lang=en&sid=1 Saba Narmcheshm sn3689@yahoo.com 10031947532846001223 10031947532846001223 No Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Nasrin Omidvar omidvar.nasrin@gmail.com 10031947532846001224 10031947532846001224 Yes Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Naser Kalantari nkalantari1334@gmail.com 10031947532846001225 10031947532846001225 No Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Parisa Amiri parisaamiri@yahoo.com 10031947532846001226 10031947532846001226 No Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Reza Sobhani reza.sobhani23@yahoo.com 10031947532846001227 10031947532846001227 No Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Zahra Feizy feizyz@yahoo.com 10031947532846001228 10031947532846001228 No Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Forouzan Salehi salehi46@yahoo.com 10031947532846001229 10031947532846001229 No Community Nutrition Department, Ministry of Health and Medical Education, Tehran, Iran.