en عمومى General پژوهشي Research <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#008080;"><strong><em>Background:</em></strong></span> Extracardiac malformations can be seen in 20-45% of infants with congenital heart disease (CHD). Chromosomal abnormalities exist in 5-10% of patients with CHD. The aim of this study was to assess the frequency of overt extra cardiac malformations in children with CHD.</span></span></p> <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#008080;"><strong><em>Methods:</em></strong></span> This descriptive epidemiologic study was conducted on 720 patients with CHD referred to the pediatric cardiac clinic of the most important south west referral center of Iran in 2014. Data were collected by studying patients&#39; files during this time.</span></span></p> <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#008080;"><strong><em>Results:</em></strong></span> Totally, 401(55.7%) and 319 (44.3%) of patients were male and female, respectively. Extracardiac malformations were diagnosed in 53 cases (7.36%) and multiple extracardiac malformations involving more than one anomaly were present in 10 cases (1.38%). The most frequent extracardiac malformations in the current study included skeletal and visceral abnormalities and then genitourinary was seen. Of all patients, 33 (4.58%) cases were affected by syndromic features of which Down syndrome was the most common.</span></span></p> <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#008080;"><strong><em>Conclusions:</em></strong></span> Investigation for extra cardiac abnormalities in patients with CHD is very important, since proper diagnosis and early treatment of these abnormalities can improve the patients&#39; outcomes. On the other hand all the patients with overt and syndromic abnormalities require investigation for a possible CHD.</span></span></p> Extracardiac Malformation, Congenital Heart Disease, Children 201 204 http://caspianjp.ir/browse.php?a_code=A-10-88-1&slc_lang=en&sid=1 Mohammad reza Khalilian khalilianomid@yahoo.com 10031947532846001470 10031947532846001470 Yes Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Abdolrahman Emami moghadam Emami_moghadam@yahoo.com 10031947532846001471 10031947532846001471 No Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Mehdi Ebrahimi 10031947532846001472 10031947532846001472 No Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Ali reza Norouzi alireza_norouzi2000@yahoo.com 10031947532846001473 10031947532846001473 No Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Fariba Alaei alaeifariba@yahoo.com 10031947532846001474 10031947532846001474 No Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Nadia Badvi Badvi-n@yahoo.com 10031947532846001475 10031947532846001475 No Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran