en تخصصي Special پژوهشي Research <p dir="ltr" style="text-align: justify"><span style="color:#008080;"><strong><em>Background</em></strong><strong><em>:</em></strong> </span>Since the reduction of mental health in patients with Thalassemia may affect the quality of life and cause dysfunction in various dimensions, so the assessment of this disorder is necessary to choose the appropriate treatment. Therefore, the aim of this study was to investigate the mental health and quality of life in patients with Thalassemia major.</p> <p dir="ltr" style="text-align: justify"><span style="color:#008080;"><strong><em>Methods:</em></strong></span> In this cross-sectional descriptive study, all Thalassemia major patients with 15 or more than 15 years old, referred to Amirkola Institute, were recruited. Mental health status and quality of life were measured via GHQ28 and SF-36 standard questionnaires, respectively.</p> <p dir="ltr" style="text-align: justify"><span style="color:#008080;"><strong><em>Results:</em></strong></span> A total of 80 women and 70 men with the mean &acirc;g&eacute; of 24.17&plusmn;7.34 were included in the study. The results indicated that in case of quality of life, the physical activity part was singnifantly correlated with stress, social dysfunction, physical symptoms and depression (P<0.001).&nbsp; Social activity, mental health and general health (except depression) were significantly correlated (P<0.001). Social dysfunction was more prevalent in men (P=0.016) but there was no significant difference between men and women in quality of life.</p> <p dir="ltr" style="text-align: justify"><span style="color:#008080;"><strong><em>Conclusions:</em></strong></span> There is an association between some of the areas of mental health and areas of quality of life, therefore a reduction in mental health status in thalassemia major patients may affect their quality of life. &nbsp;The incidence of mental disorders in this study was twofold more than previous studies and since none of patients met any psychologist during their treatment period, it is suggested that the screening test should be considered for mental disorders in Thalassemia major patients.</p> Mental Health, Quality Of Life, Thalassemia Major 54 59 http://caspianjp.ir/browse.php?a_code=A-10-43-1&slc_lang=en&sid=1 Farzan Khairkhah 1003194753284600861 1003194753284600861 No Department of Psychology Hassan Mahmoodi Nesheli mahmoodi86@yahoo.com 1003194753284600862 1003194753284600862 Yes Non-Communicable Pediatric Diseases Research Center, Amirkola Children’s Hospital, Health Research Institute Alireza yahyaei 1003194753284600863 1003194753284600863 No Non-Communicable Pediatric Diseases Research Center, Amirkola Children’s Hospital, Health Research Institute Elmira Khodabakhsh 1003194753284600864 1003194753284600864 No Babol University of Medical Science Seyed Reza Hosseini 1003194753284600865 1003194753284600865 No Social Determinants of Health (SDH) Research Center