en تخصصي Special پژوهشي Research <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14.0pt"><b><span style="color:#24a3a0">Background and Objective:</span></b> <span style="color:#0e101a;">Post-tonsillectomy bleeding is a significant concern in otolaryngological surgeries. Tranexamic acid has been extensively studied for its role in reducing bleeding, particularly in surgical settings. This study aimed to evaluate the efficacy of tranexamic acid in controlling bleeding in patients undergoing adenotonsillectomy.</span></span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0">Methods:</span></b> <span style="color:#0e101a;">A randomized clinical trial was conducted on 160 patients aged 6 to 14 years, who were candidates for tonsillectomy at the Ear, Nose, and Throat Clinic of Khatam Al-Anbiya Hospital in Zahedan in 2017. Patients were randomly divided into two groups of 80 each (case and control). The intervention group received intravenous tranexamic acid (TXA; 10 mg/kg, TRANEXIP&reg;) administered as follows: an initial dose 5 minutes prior to surgical incision, followed by subsequent doses every 6 hours for 48 hours postoperatively. The volume of bleeding during surgery, as well as 24 hours and two weeks post-surgery, was recorded for all patients.</span></span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0">Findings:</span></b> <span style="color:#0e101a;">The mean volume of intraoperative bleeding in the case group (receiving tranexamic acid) was 44.18&plusmn; 11.67 ml, compared to 55.62&plusmn;20.93 ml in the control group. This difference was statistically significant (p<0.001). Postoperative bleeding was reported in only two cases, both in the control group. The mean heart rate in the case group was 92.82&plusmn;12.15, and in the control group, it was 96.12&plusmn;13.42, but this difference was not statistically significant (p=0.105).</span></span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0">Conclusion:</span></b> <span style="color:#0e101a;">The findings of this study indicate that tranexamic acid significantly reduces the volume of intraoperative bleeding in patients undergoing adenotonsillectomy.</span></span></span></span></div> Adenotonsillectomy, Bleeding, Tranexamic acid 0 0 http://caspianjp.ir/browse.php?a_code=A-10-189-6&slc_lang=en&sid=1 Gholamali Dashti Khavidaki Drdashti50@yahoo.com 10031947532846005171 10031947532846005171 No School of Medicine, Khatam Al Anbiya Hospital, Zahedan University of Medical Sciences, Zahedan, Iran Majid Naderi dr.majidnaderi@gmail.com 10031947532846005172 10031947532846005172 No Department of Pediatrics, School of Medicine, Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Saeedeh yaghoubi yaghoubimd@yahoo.com 10031947532846005173 10031947532846005173 Yes Assistant Professor of Pediatric Infectious Disease, Department of Pediatrics, School of Medicine, Children and Adolescents Health research center, Research institute of cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran