en تخصصي Special گزارش مورد case report <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14.0pt"><b><span style="color:#24a3a0">Background and Objective:</span></b> Malaria remains a critical global health challenge, exacerbated by co-infections such as COVID-19. This report aims to enhance understanding of co-infection management and inform clinical practices in similar cases.</span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0">Case Report:</span></b> This case report presents an 11-year-old boy from Saravan, Iran, who developed fever, chills, anorexia, and lethargy, leading to a diagnosis of Plasmodium vivax malaria. His condition deteriorated, resulting in seizures and a Glasgow Coma Scale (GCS) score of 5, prompting transfer to a pediatric ICU for advanced care. Initial evaluations revealed a positive PCR test for SARS-CoV-2, alongside indications of cerebral malaria. Treatment included intravenous artesunate for malaria, remdesivir, and dexamethasone for COVID-19, with supportive care for neurological symptoms. Notably, laboratory parameters gradually normalized, and subsequent malaria smears were negative. By day four, the patient was successfully weaned off mechanical ventilation, and he showed steady improvement, ultimately being discharged in good condition on day fourteen. This case emphasizes the necessity for heightened clinical awareness regarding co-infections in endemic regions, particularly among pediatric patients.</span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0">Conclusion:</span></b> It highlights the complexities in management, necessitating comprehensive diagnostic and therapeutic strategies to address the overlapping challenges posed by simultaneous infections.</span></span></span></div> Cerebral Malaria, Child, COVID-19 0 0 http://caspianjp.ir/browse.php?a_code=A-10-336-1&slc_lang=en&sid=1 Saeedeh Yaghoubi yaghoubimd@yahoo.com 10031947532846005115 10031947532846005115 No School of Medicine, Children and Adolescents Health Research Center, Research Institute of Cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Science's, Zahedan, Iran Alireza Teimouri alirezateimouri260@gmail.com 10031947532846005116 10031947532846005116 Yes Children and Adolescents Health Research Center, Research Institute of Cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Science's, Zahedan, Iran