en تخصصي Special پژوهشي Research <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14.0pt"><b><span style="color:#24a3a0">Background and Objective:</span></b> Newborn disease scoring improves outcomes but requires arterial blood gas analysis, often unavailable in limited settings. The aim of this study was to determine whether cost-effective alternatives, such as the Modified Sick Neonatal Score (MSNS), can predict neonatal mortality.</span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0">Methods:</span></b> This cross-sectional study was conducted on the neonates who required admission to the neonatal intensive care unit (NICU) of a Medical College Hospital from February 2021 to September 2021. MSNS was done on admission, daily for 7 days and during the period of clinical deterioration. The mean (standard deviation (SD)) values at admission and the lowest recorded value were compared with the outcome. A receiver-operating characteristic curve (ROC) analysis was performed to determine the optimal cut-off value for predicting mortality.</span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0">Findings:</span></b> The mortality rate was 4.58%. The mean (SD) MSNS at admission of deceased neonates [9.04(1.612)] was significantly lower than that of improved neonates [14.68(1.610)]. The mean (SD) lowest MSNS for deceased neonates [6.23(1.177)] was significantly lower than that for improved neonates [14.5(1.893)]. The area under the curve (AUC) for admission score was 0.958, and a score of 12 predicted mortality with a sensitivity of 91% and a specificity of 95.2%. The AUC for the lowest score was 0.995, and a score of 9 had a sensitivity of 94% and a specificity of 99% for predicting mortality.</span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0">Conclusion:</span></b> Serial MSNS is a good predictor of mortality, and low scores on admission and the lowest score during hospitalization correlated well with poor outcomes.</span></span></span></div> Intensive Care, Neonatal Death, Neonatal Score, Neonatal Sick, Newborn 0 0 http://caspianjp.ir/browse.php?a_code=A-10-238-5&slc_lang=en&sid=1 Krishnan Kousika kousi.ts@gmail.com 10031947532846005397 0009-0000-4362-230X No Assistant Professor, Madha Medical College, Chennai, Junior Resident, Department of Pediatrics, Kilpauk Medical College, India Krishnaswami Devimeenakshi drdevi_1804@yahoo.in 10031947532846005398 10031947532846005398 Yes Professor of Pediatrics, Department of Pediatrics, Kilpauk Medical College, India