en تخصصي Special پژوهشي Research <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14.0pt"><b><span style="color:#24a3a0">Background and Objective:</span></b> Therapeutic response to intravenous immunoglobulin (IVIG) for the treatment of immune thrombocytopenia (ITP) in children may itself be influenced by various factors. The aim of the present study was to investigate the factors associated with the response rate to IVIG treatment in children with ITP.</span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0">Methods:</span></b> The population of this cross-sectional study included children under the age of 15 who were diagnosed with ITP and admitted to Bahrami Hospital in Tehran from 2021 to 2022. Information on each patient including age, gender, comorbidities, platelet count at diagnosis and duration of treatment at baseline was obtained by reviewing the hospital&#39;s data registry. Treatment outcomes, including treatment success and disease recurrence or chronicity, were also recorded. A p- value of 0.05 was considered significant.</span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0">Findings:</span></b> Of the 41 patients examined, 7 (17.1%) cases failed to respond to IVIG treatment and received additional treatment with corticosteroids. There was a significant difference between patients with and without response to IVIG treatment. The mean initial platelet count was 22676.47&plusmn;18514.07 and 13857.14&plusmn;7883.07 per cubic millimeter, respectively, indicating a significant difference between the two groups (P value=0.045). An initial platelet count of less than 9,000 was predictive of non-response to IVIG treatment.</span><br> <b><span style="line-height:107%"><span style="color:#24a3a0">Conclusion:</span></span></b><span style="line-height:107%"> In children with ITP, the response rate to IVIG administration was high, with patient gender and initial platelet count influencing the response. Therefore, male gender and a low platelet count on admission are predictive factors for a lower response to treatment in these patients.</span></span></span></div> Immunoglobulins, Intravenous, Response to treatment, Thrombocytopenic 0 0 http://caspianjp.ir/browse.php?a_code=A-10-178-6&slc_lang=en&sid=1 Elham Shahgholi eshahgholi@gmail.com 10031947532846005062 10031947532846005062 No Associate Professor of Pediatric Hematology and Oncology, Department of Pediatrics, School of Medicine, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran Mehrdad Sedighian m.sedighiyan86@gmail.com 10031947532846005063 10031947532846005063 No Department of Clinical Nutrition, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran Mohammad Kajiyazdi Mkajiyazdi50@gmail.com 10031947532846005064 10031947532846005064 Yes Associate Professor of Pediatric Hematology and Oncology, Department of Pediatrics, School of Medicine, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran Leili Koochak Zadeh l.koochakzadeh@gmail.com 10031947532846005065 10031947532846005065 No Assistant Professor of Hematology & Oncology, Department of Pediatrics, School of Medicine, Childrens Medical Center, Tehran University of Medical Sciences, Tehran, Iran Maryam Amirmohseni Maryam.amirmohseni@gmail.com 10031947532846005066 10031947532846005066 No Tehran University of Medical Sciences, Tehran, Iran