en تخصصي Special گزارش مورد case report <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14.0pt"><b><span new="" roman="" times=""><span style="color:#24a3a0">Background and Objective:</span></span></b><span new="" roman="" times=""> Gestational alloimmune liver disease (GALD) is a rare hepatic disorder that begins during the intrauterine period with alloimmune mechanisms. The newborn shows signs of hyperbilirubinemia, hypoalbuminemia, and signs of liver failure. Because of the alloimmune mechanism, exchange transfusions and intravenous immunoglobulins are used as the treatment of choice.</span></span><br> <span style="line-height:14.0pt"><b><span new="" roman="" times=""><span style="color:#24a3a0">Case Report: </span></span></b><span new="" roman="" times="">We present a 15-day-old male newborn with conjugated hyperbilirubinemia, mild skin darkening and poor feeding that progressed to coagulopathy, increased serum ferritin and liver failure. On clinical suspicion and after a biopsy, the patient was treated but died and the diagnosis of the disease was confirmed by autopsy. The baby died despite exchange transfusion in combination with intravenous immunoglobulin and necropsy confirmed the presence of blue granules in the panlobular and also within the Kupffer cells, in a specific iron staining consistent with the diagnosis of GALD.</span></span><br> <span style="line-height:14.0pt"><b><span new="" roman="" times=""><span style="color:#24a3a0">Conclusion:</span></span></b><span new="" roman="" times=""> Despite the fact that slightly darker skin in direct hyperbilirubinemia is due to phototherapy, a diagnosis of GALD should be considered in any infant with cholestasis and liver failure.</span></span></span></span></div> Gestational Alloimmune Liver Disease, Hemochromatosis, Hyperbilirubinemia, Neonate 21 21 http://caspianjp.ir/browse.php?a_code=A-10-290-1&slc_lang=en&sid=1 Mousa Ahmadpour-kacho mousa_ahmadpour@hotmail.com 10031947532846004658 10031947532846004658 No Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran Yadollah Zahedpasha zypasha@gmail.com 10031947532846004659 10031947532846004659 No Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran Samira Pournajaf samirapournajaf@yahoo.com 10031947532846004660 10031947532846004660 Yes Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran Shahla Rahbar sh.rahbar93@gmail.com 10031947532846004661 0009-0003-1353-2065 No The Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, IR Iran khadijeh Ebrahimi kiasari khadijeebrahimi46@gmail.com 10031947532846004662 10031947532846004662 No The Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, IR Iran