en تخصصي Special پژوهشي Research <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="line-height:14.0pt"><b><span style="color:#24a3a0">Background and Objective:</span></b> One of the leading causes of acquired heart disease in the world today is Kawasaki disease [KD], an acute systemic vasculitis in children. The purpose of this study was to identify the clinical and laboratory manifestations of children with KD admitted to the 17^th Shahrivar Educational Hospital in Rasht, Iran.</span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0"><span style="letter-spacing:.2pt">Methods:</span></span></b> <span style="letter-spacing:.2pt">We retrospectively studied the cases of 75 children with KD who were admitted to the 17^th Shahrivar Educational Hospital in Rasht between 2011 and 2018. The frequency distribution of age, sex, seasonal prevalence, clinical manifestations including fever, skin rash, changes in the lips and oral cavity, conjunctivitis, changes in the extremities, and cervical lymphadenopathy; laboratory findings including platelets and leukocyte count, erythrocyte sedimentation rate [ESR], and C-reactive protein [CRP]; and response to treatment were studied. The obtained data were analyzed using descriptive statistical methods.</span></span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0">Findings:</span></b> Out of 75 patients, the most common clinical manifestations were fever [100%], skin rash [78.67%], alterations to the lips and mouth [74.67%], bilateral non-purulent conjunctivitis [64%], changes in the extremities [46.67%], and cervical lymphadenopathy&nbsp;[38.67%], respectively. Among 75 patients, 70 [93.33%] had ESR above 40 mm/h, and 63 patients [84%] had high C-reactive protein [CRP]. Sixty percent of children had incomplete Kawasaki disease. Eight of our patients [10.6%] developed coronary heart disease.</span><br> <span style="line-height:15.0pt"><b><span style="color:#24a3a0">Conclusion:</span></b> In this study, the most frequent principal clinical manifestations were fever, skin rash, and alterations in the oral cavity and lips. Cervical lymphadenopathy had the lowest prevalence. Increased ESR and CRP were also the most common laboratory findings.</span></span></span></div> Child, Coronary Aneurysm, Kawasaki Disease 14 14 http://caspianjp.ir/browse.php?a_code=A-10-267-1&slc_lang=en&sid=1 Houman Hashemian hashemian@gums.ac.ir 10031947532846004696 10031947532846004696 Yes Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Fateme Ebrahimzadeh dr.fatemeebrahimzadeh@gmail.com 10031947532846004697 10031947532846004697 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.