en تخصصي Special كاربردي Applicable <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#339999;"><b>Background and Objective:</b></span><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="color:black"> Attention-deficit/hyperactivity disorder (ADHD) is a disorder of childhood and adolescence characterized by persistent symptoms of increased activity and impulsive behavior. Totally, 2-5% of schoolchildren exhibit specific and comprehensive symptoms of ADHD. The aim of the present study was to investigate the comparison of risperidone and aripiprazole in the treatment of ADHD children.</span></span></span><br> <span style="line-height:normal"><span style="unicode-bidi:embed"><span style="color:#339999;"><b>Methods:</b></span><span style="color:black"> A literature search was performed in the electronic databases of Embase, PubMed, Web of Science, Scopus, and Google Scholar for articles published from inception between 2005 and 2022. Persian keywords and their English equivalents in Mesh were used to search all domestic and foreign articles in all databases. </span>This systematic review was conducted according to the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines and the quality of articles was assessed using the risk of bias checklist.</span></span><br> <span style="line-height:normal"><span style="unicode-bidi:embed"><span style="color:#339999;"><b>Findings:</b></span><span style="color:black"> Of the 320 articles initially identified, 8 were eventually included, with 4 articles published from Iran and 4 articles from other countries. Totally, 50% of the studies were related to Iran. The age of the studied subjects ranged from 3 to 18 years, and 283 children were studied and investigated. In 90% of the studies, with p>0.05, there was no significant difference in the efficacy of the two drugs, risperidone and aripiprazole.</span><span style="font-size:14.0pt"></span></span></span><br> <span style="line-height:normal"><span style="unicode-bidi:embed"><span style="color:#339999;"><b>Conclusion:</b></span><span style="color:black"> In general, both risperidone and aripiprazole are effective for the treatment of ADHD and can be used according to the clinical conditions and medical history of the child.</span></span></span></span></span></div> Aripiprazole, Attention Deficit and Hyperactivity Disorder, Child, Risperidone 0 0 http://caspianjp.ir/browse.php?a_code=A-10-259-1&slc_lang=en&sid=1 Armon Massoodi armonmassoodi@gmail.com 10031947532846004840 10031947532846004840 No Assistant Professor of child and adolescent Psychiatry, Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Sara Dehbozorgi Dehbozorgi.sa@gmail.com 10031947532846004841 10031947532846004841 No Research Center for Psychiatry and behavior Science, Shiraz University of Medical Sciences, Shiraz, Iran Nasim Nekouei Shoja nnekouei@gmail.com 10031947532846004842 10031947532846004842 No Department of Psychiatry, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Seyedeh Maryam Zavarmousavi maryamzavarmousavi@gmail.com 10031947532846004843 10031947532846004843 Yes Assistant Professor of Children and Adolescents' Psychiatry, Department of Psychiatry, Shafa Hospital, Guilan University of Medical Sciences, Rasht, Iran