en عمومى General پژوهشي Research <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:15.0pt"><b><span style="color:#24a3a0">Background and Objective:</span></b> Neonatal thrombocytopenia (NTP) is one of the most common neonatal hematological disorders. The causes of NTP are very various, leading to large differences in the clinical profile of the affected neonates. Therefore, the aim of this study was to investigate the characteristics, clinical diagnoses and short-term outcomes of NTP in Bahrami Children&#39;s Hospital, Iran.</span><br> <span style="line-height:15.0pt"><b><span style="color:#24a3a0"><span style="letter-spacing:.2pt">Methods:</span></span></b> <span style="letter-spacing:.2pt">This descriptive retrospective cross-sectional study was conducted on all neonates admitted to the neonatal intensive care unit (NICU) of Bahrami Children&#39;s Hospital in 2017-2019. The infants diagnosed with NTP, defined as a platelet count of <150000 on at least 2 occasions, were retrospectively evaluated. Data on patients&#39; NTP and short-term outcomes were reported. Incomplete medical records were excluded from the study. </span></span><br> <span style="line-height:15.0pt"><b><span style="color:#24a3a0">Findings:</span></b> Out of 2000 neonates, 210 patients were diagnosed with NTP with a prevalence of 10.5%. Totally, 60% and 71.4% of infants were premature and underweight, respectively. Moreover, 30 and 20.9% of infants had premature and severe NTP, respectively. The most common clinical diagnosis was sepsis (68.1%). The mean length of stay in NICU was 12.3&plusmn;9.5 days. Additionally, 20.9% of infants had at least one episode of severe hemorrhage, received a platelet transfusion, and 10.4% of infants expired during their NICU stay.</span><br> <b><span style="line-height:107%"><span style="color:#24a3a0">Conclusion:</span></span></b> <span style="line-height:107%">The prevalence of NTP was 10.5%. Despite the relatively high prevalence of preterm birth, low-birth weight and sepsis, the majority of our neonates recovered. Prospective studies are recommended to investigate the role of each predisposing factor in the development and outcome of NTP.</span></span></span></div> Neonatal Thrombocytopenia, NICU, Diagnosis, Management, Outcome 717 722 http://caspianjp.ir/browse.php?a_code=A-10-178-3&slc_lang=en&sid=1 Mahbod Kaveh kavehmah@sina.tums.ac.ir 10031947532846004186 10031947532846004186 No Associate Professor of neonatal-perinatal medicine department of pediatrics , Bahrami hospital,Tehran University of Medical Sciences, Tehran, Iran Samuel Berchi Kankam samkankam81@gmail.com 10031947532846004187 10031947532846004187 No Tehran University of Medical Sciences, Tehran, Iran Ahmad Ziaoddin ahmadziaoddin@yahoo.com 10031947532846004188 10031947532846004188 No Tehran University of Medical Sciences, Tehran, Iran Abolfazl Hakimpour Abolfazl.hakim@gmail.com 10031947532846004189 0009-0007-0431-9958 No Tehran University of Medical Sciences Mohammad Kajiyazdi mkajiyazdi@sina.tums.ac.ir 10031947532846004190 10031947532846004190 Yes Pediatric Hematology and Oncology Department, Tehran University of Medical Sciences, Tehran, Iran