en عمومى General پژوهشي Research <p style="font-style: normal; text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14.0pt"><b><span style="color:#24a3a0">Background and Objective:</span></b> The level of fasting blood sugar (FBS) must be regularly monitored in diabetic patients. Unlike blood, saliva sampling is a noninvasive technique, saliva glucose was evaluated in controlled and uncontrolled type 1 diabetes mellitus (T₁DM) children in this study.</span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0"><span style="letter-spacing:.2pt">Methods:</span></span></b> <span style="letter-spacing:.2pt">In this cross-sectional study, 40 uncontrolled T₁DM and 40 controlled T₁DM children were enrolled. The FBS and stimulated and unstimulated saliva glucose was assayed by the GOD-POP method and analyzed by an unpaired Student&rsquo;s t-test.</span></span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0">Findings:</span></b> Serum and stimulated saliva glucose levels were higher in the uncontrolled T₁DM than that in the controlled T₁DM. However, there was no significant difference in unstimulated saliva between the two groups. Serum glucose had a positive correlation with unstimulated (r=0.403; p<0.001) and stimulated (r=0.232; p=0.005) salivary glucose levels. The stimulated and unstimulated salivary flow rate was significantly lower in uncontrolled T₁DM.</span><br> <b><span style="line-height:107%"><span style="color:#24a3a0">Conclusion:</span></span></b> <span style="line-height:107%">Stimulated salivary glucose level similar to serum was higher in uncontrolled T₁DM than in controlled T₁DM children. Therefore, it may be suitable as an alternative for serum glucose to monitor T₁DM patients.</span></span></span></p> Diabetes Mellitus, Glucose, Saliva 643 647 http://caspianjp.ir/browse.php?a_code=A-10-200-1&slc_lang=en&sid=1 Yasmin Sheikhhassani Yasminsheikhhassani@yahoo.com 10031947532846004140 10031947532846004140 No Department of Pediatrics, Dental Research Center, Mashhad University of Medical Science, Mashhad , Iran Mina Khayamzadeh mkhayamzadeh@yahoo.com 10031947532846004141 10031947532846004141 No Department of Oral Medicine, Dental Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Iraj Mirzaii-Dizgah emirzaii@alumnus.tums.ac.ir 10031947532846004142 10031947532846004142 Yes Department of Physiology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran Hesam Sanaei Sanaeihesam@yahoo.com 10031947532846004143 10031947532846004143 No Doctor of Dental Surgery (DDS), Bouvardia Medical Center,Salmiya,Kuwait