en تخصصي Special پژوهشي Research <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="line-height:14.0pt"><b><span style="color:#24a3a0">Background and Objective:</span></b> Thalassemia is one of the most common genetic diseases that affect all aspects of quality of life (QOL). The present study was conducted to evaluate the QOL of children and adolescents with thalassemia major.</span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0"><span style="letter-spacing:.2pt">Methods:</span></span></b> <span style="letter-spacing:.2pt">This descriptive-analytical-cohort study was performed on patients with thalassemia major referred to Ali Asghar Hospital in Zahedan in 2017-2018. A 26-item World Health Organization Quality of Life questionnaire (WHOQOL-Bref) was used to assess patients&#39; QOL. The questionnaire of this study had two major components; 1- General information like age, sex, education, numbers of transfusions and heart disease and 2- Questions regarding physical and mental health. The result of the questionnaire yielded a score depending on the answers provided by the patients. Data were analyzed using the independent t-test and ANOVA.</span></span><br> <span style="line-height:14.0pt"><b><span style="color:#24a3a0">Findings:</span></b> Out of the 250 participants in the study, 123 and 127 ones were male and female, respectively. The mean QOL score was 262.735&plusmn;13.785. There was no significant difference between boys and girls in the QOL score. But there was a significant difference in the QOL based on the education (P=0.000), heart disease (P=0.000) and number of blood transfusions (P=0.001).</span><br> <b><span style="line-height:107%"><span style="color:#24a3a0">Conclusion:</span></span></b> <span style="line-height:107%">This study revealed that patients with thalassemia major required special attention to various aspects of their lives as their lower QOL negatively impacted them. Providing more and better medical and rehabilitation services to this group seems to be necessary.</span></span></span><span dir="RTL"></span><span dir="RTL"></span></div> Children, Quality of Life, Thalassemia Major 8 8 http://caspianjp.ir/browse.php?a_code=A-10-189-3&slc_lang=en&sid=1 Majid Naderi dr.naderi@zaums.ac.ir 10031947532846004643 10031947532846004643 No Associate Professor of Pediatric Hematology and Oncology, Genetics and Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Maryam Lashkaripour dr_lashkaripour@yahoo.com 10031947532846004644 10031947532846004644 No Associate Professor of Psychiatry, Department of Psychiatry, School of Medicine, Baharan Psychiatric Hospital, Zahedan University of Medical Sciences, Zahedan, Iran Saeedeh Yaghoubi s.yaghoubi@zaums.ac.ir 10031947532846004645 10031947532846004645 No Assistant Professor of Zahedan University of Medical Sciences, Zahedan, Iran Ilia Mirzaei 10031947532846004646 10031947532846004646 Yes Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran