en تخصصي Special پژوهشي Research <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#339999;"><strong>Background and Objective:</strong></span> Physical abnormalities in patients with beta-thalassemia major might potentially have a negative impact on the patient&#39;s body image (BI). The aim of the current study was to evaluate the BI of adolescents with thalassemia in Southeast Iran in comparison with healthy peers<span dir="RTL">.</span><br> <span style="color:#009999;"><strong>Methods:</strong></span> This cross-sectional study was performed on 94 individuals in Ali Asghar Hospital in Zahedan in 2020. A total of 46 teenagers with beta-thalassemia major and 48 healthy individuals, both groups in a range of 11-18 years of age, were entered into the study. Evaluation of the BI was performed by using the Multidimensional Body-Self Relations Questionnaire (MBSRQ). All statistical analyses were performed by SPSS-22 software. Obtained data were displayed by using descriptive statistical methods. Independent t-test and ANOVA were applied to compare the scores of different groups. The P values less than 0.05 were considered statistically significant.<br> <span style="color:#009999;"><strong>Findings:</strong> </span>The statistical analyses revealed a significant difference in the appearance evaluation, fitness evaluation, fitness orientation, and body areas satisfaction scales, with a higher score of the thalassemia patients&nbsp;group in the first three items, (p<0.05). The difference between the two groups was not significant in appearance,&nbsp;orientation and subjective weight scales (P>0.05).<br> <span style="color:#009999;"><strong>Conclusion:</strong> </span>An unfavorable BI in adolescents with thalassemia, as a kind of psychiatric disorder, emphasizes the need for emotional and social supports by family, medical staff and peers.</span></span></div> Adolescence, Body Image, Thalassemia Major 502 508 http://caspianjp.ir/browse.php?a_code=A-10-189-1&slc_lang=en&sid=1 Majid Naderi majid_naderi2000@yahoo.com 10031947532846002816 10031947532846002816 No Associate Professor, Department of Pediatrics, Genetics of Non-Communicable Disease Research Center; Zahedan University of Medical Sciences, Zahedan, Iran. ORCID ID: 0000-0002-4566-8202 Mahvash Raghibi yaghoubimd@yahoo.com 10031947532846002817 10031947532846002817 No Associate Professor Psychology, University of Sistan and Baluchestan, Zahedan, Iran Hassan Mahmoodi Nesheli mahmoodi86@yahoo.com 10031947532846002818 10031947532846002818 No Associate Professor of Pediatric Hematology and Oncology, Department of Pediatrics, Non Communicable Pediatric Disease Research Center Health Research Institute, Babol University of Medical Sciences, Babol, Iran Emliya Sadat Mirbod yaghoubimd@yahoo.com 10031947532846002819 10031947532846002819 No Master of Psychology, Sistan and Baluchestan University Saeedeh Yaghoubi yaghoubimd@yahoo.com 10031947532846002820 10031947532846002820 Yes Assistant Professor, Department of Pediatrics, Zahedan University of Medical Science, Zahedan, Iran,