en عمومى General گزارش مورد case report <span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong><em><span style="color:#006666;">Background:</span> </em></strong>Levamisole is an anthelmintic drug used in the treatment of patients with a diagnosis of steroid-dependent nephrotic syndrome. Skin rash has been reported as a drug side effect, but adverse events are really rare.<br> <span style="color:#006666;"><strong><em>Case report:</em></strong></span> The case presented in this article was a 14-year-old boy with steroid-dependent nephrotic syndrome, treated with levamisole due to frequent relapse. He was admitted with rash, weakness, fatigue, fever, and weight loss. Levamisole was discontinued, and the patient&rsquo;s condition improved in the following two weeks. One year later, the nephrotic syndrome relapsed, and he received prednisolone and levamisole. He was admitted to the hospital six months after re-administration of these drugs because of vasculopathy, and unfortunately, he died due to disseminated intravascular coagulation (DIC).<br> <span style="color:#006666;"><strong><em>Conclusions:</em></strong></span> Although levamisole is a suitable and cost-effective therapy for remission maintenance in steroid-dependent nephrotic syndrome, it is highly recommended to discontinue the drug without re-administration in case of reoccurring adverse effects, especially skin rash and systemic reaction, in addition to close monitoring of the patients under treatment.</span></span> Child, Levamisole, Nephrotic Syndrome, Rash, Vasculopathy 430 433 http://caspianjp.ir/browse.php?a_code=A-10-153-1&slc_lang=en&sid=1 mahbobeh neamatshahi mahneamatshahi@yahoo.com 10031947532846002778 10031947532846002778 No Department of community Medicine, Faculty of Medicine, Research Center Social Determinants health, Sabzevar University of Medical Sciences, Iran Elham Navipour Elham.navipour@gmail.com 10031947532846002779 10031947532846002779 No Department of Anesthesiology, Faculty of Paramedicine, Sabzevar University of Medical Sciences, Sabzevar, Iran Zahra Barabadi z.barabadi@umsha.ac.ir 10031947532846002780 10031947532846002780 No Department of Tissue Engineering, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Aghil Keykhosravi drakeykhosravi@yahoo.com 10031947532846002781 10031947532846002781 Yes Department of pediatrics, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran