en تخصصي Special پژوهشي Research <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#009999;"><strong><em>Background:</em></strong></span> Osteogenesis imperfecta (OI) is a group of genetic disorders characterized by significant variation, which is due to qualitative or quantitative defects in the production of collagen. The prevalence of cardiovascular abnormalities in OI patients is unknown. This study aimed at investigating cardiac involvement in OI children using Echocardiography.<br> <span style="color:#009999;"><strong><em>Methods:</em></strong></span> This cross-sectional research was performed on 65 patients diagnosed with OI in a children&rsquo;s hospital in Tehran, Iran, from 2011 to 2012. The classification of OI was based on the Sillence criteria. A consultation with a skilled pediatric cardiologist was scheduled for the subjects, and echocardiography was carried out, using the Samsung HS70 ultrasonography machine (Medison Co., Seoul; South Korea). Data analysis was done using SPSS-22, chi-square and t-tests. The exact P-values were determined and P-values <0.05 were regarded significant.<br> <span style="color:#339999;"><strong><em>Results:</em></strong></span> Sixty percent of patients were male and 40% were female, with an average age of 6.95&plusmn;4.36 years (ranged from 2 months to 17 years), respectively. Based on the Sillence classification, 20% of the cases were categorized in subtype I, 47.7% in subtype III, and 32.3% in subtype IV. The prevalence of aortic root dilatation, mitral valve prolapse (MVP), mitral regurgitation (MR) and tricuspid regurgitation (TR) were 13.8%, 15.38%, 7.6% and 15.38%, respectively. The MVP and female gender showed a significant relationship, whereas there was no relationship between MVP and patients&rsquo; subgroups.<br> <strong><em><span style="color:#339999;">Conclusions:</span> </em></strong>Due to the significance of cardiac involvement in OI, echocardiography is recommended for all children with OI.</span></span> Child, Echocardiography , Osteogenesis Imperfecta 329 333 http://caspianjp.ir/browse.php?a_code=A-10-133-1&slc_lang=en&sid=1 Mohamadreza Alaei dralaeimr@sbmu.ac.ir 10031947532846002701 10031947532846002701 No Department of Endocrinology and Metabolism, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran- Iran Asieh Mosallanejad mosalladr@sbmu.ac.ir 10031947532846002702 10031947532846002702 Yes Imam Hosein Medical Center, Shahid Beheshti University of Medical Science, Tehran,Iran Shahrzad Fallah shahrzad.fallah@sbmu.ac.ir 10031947532846002703 10031947532846002703 No Department of immunology and allergy, Shahid Beheshti University of Medical Sciences, Tehran- Iran Marjan Shakiba shakibamarjan@yahoo.com 10031947532846002704 10031947532846002704 No Department of Endocrinology and Metabolism, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran- Iran Hedyeh Saneifard hediehsf@yahoo.com 10031947532846002705 10031947532846002705 No Department of Endocrinology and Metabolism, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran- Iran Fariba Alaei alaeifariba@yahoo.com 10031947532846002706 10031947532846002706 No Mofid Children Hospital,Shahid Beheshti University of Medical Science,Tehran, Iran Reza Shiari shiareza@yahoo.com 10031947532846002707 10031947532846002707 No Mofid Children Hospital,Shahid Beheshti University of Medical Science,Tehran, Iran Behnam Sobouti sobouti.b@iums.ac.ir 10031947532846002708 10031947532846002708 No Iran University of Medical Sciences, Tehran- Iran