en تخصصي Special پژوهشي Research <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="line-height:normal"><b><span style="color:#009999">Background and Objective:</span></b> <span style="color:#000000;">Wilms tumor (nephroblastoma) is the most common renal malignancy in children. Treatment typically involves nephrectomy and chemotherapy, with radiotherapy reserved for selected cases. These treatments may adversely affect renal function. This study aimed to evaluate changes in renal function in children diagnosed with Wilms tumor.</span></span><br> <span style="line-height:normal"><b><span style="color:#009999">Methods:</span></b> <span style="color:#000000;">This retrospective cohort study included patients <18 years who had completed treatment for Wilms tumor at least five years before the assessment. Demographic and clinical characteristics, serum creatinine and urea levels, estimated glomerular filtration rate (eGFR), and renal ultrasonography findings were assessed at baseline and at the last follow-up.</span></span><br> <span style="line-height:normal"><b><span style="color:#009999">Findings:</span></b> <span style="color:#000000;">A total of 32 patients were evaluated. Their mean age was 9 &plusmn; 2.6 years, and 20 (62.5%) were female. At diagnosis, 12 patients (37.5%) had stage II disease and 10 (31.3%) had stage III disease. Total nephrectomy was performed in 93.8% of patients, and 7 (21.9%) received neoadjuvant chemotherapy. Four patients (12.5%) died during follow-up; these deaths were not directly attributable to renal dysfunction. At baseline, 4 patients (12.5%), 26 (81.2%), and 2 (6.3%) were classified as having stage 1, stage 2, and stage 3 chronic kidney disease (CKD), respectively, based on eGFR. At the five-year assessment, the corresponding numbers were 2 (6.3%), 22 (68.7%), and 8 (25.0%), respectively. Contralateral kidney hypertrophy was observed in 25% of patients during follow-up.</span></span><br> <span style="line-height:normal"><b><span style="color:#009999">Conclusion:</span></b> <span style="color:#000000;">Renal function may deteriorate over time in children treated for Wilms tumor, underscoring the importance of long-term follow-up and regular monitoring of renal function.</span></span></span></span></div> Adjuvant Chemotherapy, Nephrectomy, Nephroblastoma, Renal function, Wilms Tumor 0 0 http://caspianjp.ir/browse.php?a_code=A-10-367-1&slc_lang=en&sid=1 Fateme Fazli fatemehfazli67@gmail.com 10031947532846005475 10031947532846005475 Yes Department of Pediatrics, School of Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran Ali Ghasemi GhasemiAl@mums.ac.ir 10031947532846005476 10031947532846005476 No Department of Pediatrics Hematology & Oncology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Anoush Azarfar azarfara@mums.ac.ir 10031947532846005477 10031947532846005477 No Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Hamid Farhangi Farhangih@mums.ac.ir 10031947532846005478 10031947532846005478 No Department of Pediatrics Hematology & Oncology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran