Volume 11, Issue 1 (3-2025)
CJP 2025, 11(1): e1 |
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Dashti Khavidaki G, Naderi M, yaghoubi S. The effect of tranexamic acid on the control of postoperative bleeding in children undergoing adenotonsillectomy. CJP 2025; 11 (1)
URL: http://caspianjp.ir/article-1-263-en.html
URL: http://caspianjp.ir/article-1-263-en.html
Assistant Professor of Pediatric Infectious Disease, Department of Pediatrics, School of Medicine, Children and Adolescents Health research center, Research institute of cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran , yaghoubimd@yahoo.com
Abstract: (30 Views)
Background and Objective: Bleeding after tonsillectomy is one of the most important issues in otolaryngology. Extensive research has been done on the role of tranexamic acid in reducing bleeding, especially in surgeries. Therefore, this study aimed to determine the effect of tranexamic acid in controlling the bleeding of patients undergoing adenotonsillectomy.
Methods: This randomized clinical trial study was performed on 160 patients aged 6 to 14 years who were candidates for tonsillectomy referred to the ENT Clinic of Khatam Al-Anbiya Hospital in Zahedan in 2017. Patients were divided into two groups of 80 (case and control). Bleeding during surgery and 24 hours and two weeks after surgery were recorded for all patients.
Findings: The mean volume of intraoperative bleeding in the case group (receiving tranexamic acid) was 44.18 ± 11.67 ml and in the control group was 55.62 ± 20.93 ml. Mean bleeding was significantly lower in the tranexamic acid recipient group). (p <0.001). Only two cases in the control group reported clear postoperative bleeding. The mean heart rate in the case group was 92.82 ± 12.15 and in the control group was 96.12 ± 13.42, but this difference did not show a significant difference between the two groups (p = 0.105).
Conclusion: Based on the results of the present study, it was observed that tranexamic acid significantly reduced the amount of intraoperative bleeding in the case group. However, there was no difference in the reported light bleeding at 24 hours and 2 weeks after surgery and the heart rate.
Methods: This randomized clinical trial study was performed on 160 patients aged 6 to 14 years who were candidates for tonsillectomy referred to the ENT Clinic of Khatam Al-Anbiya Hospital in Zahedan in 2017. Patients were divided into two groups of 80 (case and control). Bleeding during surgery and 24 hours and two weeks after surgery were recorded for all patients.
Findings: The mean volume of intraoperative bleeding in the case group (receiving tranexamic acid) was 44.18 ± 11.67 ml and in the control group was 55.62 ± 20.93 ml. Mean bleeding was significantly lower in the tranexamic acid recipient group). (p <0.001). Only two cases in the control group reported clear postoperative bleeding. The mean heart rate in the case group was 92.82 ± 12.15 and in the control group was 96.12 ± 13.42, but this difference did not show a significant difference between the two groups (p = 0.105).
Conclusion: Based on the results of the present study, it was observed that tranexamic acid significantly reduced the amount of intraoperative bleeding in the case group. However, there was no difference in the reported light bleeding at 24 hours and 2 weeks after surgery and the heart rate.
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