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:: Volume 3, Issue 2 (9-2017) ::
CJP 2017, 3(2): 224-228 Back to browse issues page
Relationship between thyroid stimulating hormone and metabolic syndrome in overweight/obese children
Saba Narmcheshm , Nasrin Omidvar , Naser Kalantari , Parisa Amiri , Reza Sobhani , Zahra Feizy , Forouzan Salehi
PhD Nutrition Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , omidvar.nasrin@gmail.com
Abstract:   (882 Views)

Background: Background: Obesity, especially central obesity is related to many endocrine abnormalities, such as thyroid dysfunctions. Elevated levels of thyroid stimulating hormone (TSH) is common in obese children, however, it is not clear if such condition is associated with increased cardiovascular risk factors. The study aimed to determine the association between levels of TSH in overweight and obese children with components of metabolic syndrome (Mets).
Methods: The study sample included 197 overweight/obese 6-7 year old children in Tehran, Iran. Anthropometric (weight, waist circumference and height), metabolic (high-density lipoprotein cholesterol, triglycerides and fasting blood glucose) and hormonal (TSH) variables, as well as blood pressure were measured. Mets was defined according to Cook definition.
Results: Totally, 20.3% and 79.7% of children were overweight and obese, respectively. Elevated levels of TSH were diagnosed in 10 subjects (5.1%), while Mets was seen in 35.4%. The most frequent component of Mets was abdominal obesity (72.5%). A weak positive correlation between BMI for age, Z scores and TSH level (r =0.11, P value= 0.123) was observed only in girls (r=0.2, P value= 0.034). TSH was not associated with components of Mets.
Conclusion: Elevated TSH levels may be found in obese children; however, the association between TSH elevation and cardiovascular disease risk factors, including components of metabolic syndrome needs further investigation.

Keywords: Hypothyroidism, Overweight, Metabolic Syndrome, Cardio Vascular Risk Factor
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Type of Study: Research | Subject: Special
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Narmcheshm S, Omidvar N, Kalantari N, Amiri P, Sobhani R, Feizy Z et al . Relationship between thyroid stimulating hormone and metabolic syndrome in overweight/obese children. CJP. 2017; 3 (2) :224-228
URL: http://caspianjp.ir/article-1-66-en.html


Volume 3, Issue 2 (9-2017) Back to browse issues page
مجله کودکان کاسپین Caspian Journal of Pediatrics
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